Gene Name |
GDF11 BMP11 |
Protein Name |
GDF11 |
Immunogen |
Synthesized peptide derived from human GDF11 |
Specificity |
This antibody detects endogenous levels of GDF11 at Human/Mouse/Rat |
Formulation |
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
Source |
Rabbit |
Dilution |
WB 1:500-2000 |
Puification |
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
MolecularWeight(Da) |
44770 |
Concentration |
1 mg/ml |
Storage |
-20°C/1 year |
Subcellular Location |
extracellular region,extracellular space,nucleoplasm,intracellular membrane-bounded organelle,protein complex, |
Background |
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein plays a role in the development of the nervous and other organ systems, and may regulate aging. [provided by RefSeq, Aug 2016], |
Function |
function:Secreted signal that acts globally to specify positional identity along the anterior/posterior axis during development. Play critical roles in patterning both mesodermal and neural tissues and in establishing the skeletal pattern.,similarity:Belongs to the TGF-beta family.,subunit:Homodimer; disulfide-linked., |