| Gene name: | FFAR1(GPR40); |
| Protein name: | Free fatty acid receptor 1; |
| Alternative: | G-protein coupled receptor 40; |
| Organism: | Human (Homo sapiens). |
| Sub Unit: | N/A |
| Function: | Receptor for medium and long chain saturated and unsaturated fatty acids. Binding of the ligand increase intracellular calcium concentration and amplify glucose-stimulated insulin secretion. The activity of this receptor is mediated by G-proteins that activate phospholipase C. Seems to act through a G(q) and G(i)-mediated pathway. |
| Subcellular Location: | Cell membrane Multi-pass membrane protein |
| Sequence length: | 300 |
| Sequence: | |
| 50: | MDLPPQLSFG | LYVAAFALGF | PLNVLAIRGA | TAHARLRLTP | SLVYALNLGC | |
| 100: | SDLLLTVSLP | LKAVEALASG | AWPLPASLCP | VFAVAHFFPL | YAGGGFLAAL | |
| 150: | SAGRYLGAAF | PLGYQAFRRP | CYSWGVCAAI | WALVLCHLGL | VFGLEAPGGW | |
| 200: | LDHSNTSLGI | NTPVNGSPVC | LEAWDPASAG | PARFSLSLLL | FFLPLAITAF | |
| 250: | CYVGCLRALA | RSGLTHRRKL | RAAWVAGGAL | LTLLLCVGPY | NASNVASFLY | |
| 300: | |
| 3D Structure: | N/A |
| STRING: | 9606.ENSP00000246553 |
| UniGene: | Hs.248127 |
| SMR: | O14842 |
| MIM: | 603820 |
| Pfam: | PF00001 |
| String: | O14842 |
| KEGG: | hsa:2864 |
| Uniprot: | O14842 |