| Gene name: | Ikbkg(Nemo); |
| Protein name: | NF-kappa-B essential modulator(NEMO); |
| Alternative: | NF-kappa-B essential modifier;IkB kinase-associated protein 1(IKKAP1);Inhibitor of nuclear factor kappa-B kinase subunit gamma(I-kappa-B kinase subunit gamma;IKK-gamma;IKKG;IkB kinase subunit gamma); |
| Organism: | Rat (Rattus norvegicus). |
| Sub Unit: | Homodimer; disulfide-linked. Component of the I-kappa-B-kinase (IKK) core complex consisting of CHUK, IKBKB and IKBKG; probably four alpha/CHUK-beta/IKBKB dimers are associated with four gamma/IKBKG subunits. The IKK core complex seems to associate with regulatory or adapter proteins to form a IKK-signalosome holo-complex. The IKK complex associates with TERF2IP/RAP1, leading to promote IKK-mediated phosphorylation of RELA/p65. Part of a complex composed of NCOA2, NCOA3, CHUK/IKKA, IKBKB, IKBKG and CREBBP. Interacts with COPS3, CYLD, NALP2, TRPC4AP and LRDD. Interacts with ATM; the complex is exported from the nucleus. Interacts with TRAF6. Interacts with TANK; the interaction is enhanced by IKBKE and TBK1. Part of a ternary complex consisting of TANK, IKBKB and IKBKG (By similarity). Interacts with ZFAND5. |
| Function: | Regulatory subunit of the IKK core complex which phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Also considered to be a mediator for TAX activation of NF-kappa-B. Could be implicated in NF-kappa-B-mediated protection from cytokine toxicity. Essential for viral activation of IRF3. |
| Subcellular Location: | Cytoplasm Nucleus |
| Sequence length: | 412 |
| Sequence: | |
| 50: | MSRHLWKNQL | SEMVQPSGGP | AEDQDMLGEE | SSLGKPAMLH | LPSEQGTPET | |
| 100: | LQRCLEENQE | LRDAIRQSNQ | MLRERCEELL | HFQVSQREEK | EFLMCKFQEA | |
| 150: | RKLVERLSLE | KLDLRRQREQ | ALEDLEHLKK | CQQQMAEDKA | SVKAQVTSLL | |
| 200: | GELQESQSRL | EAATKERQTL | EGRIRAVSEQ | VRQLESEREV | LQQQHSVQVD | |
| 250: | QLRMQNQSVE | AALRMERQAA | SEEKRKLAQL | QAAYHQLFQD | YDSHIKSSKG | |
| 300: | MQLEDLRQQL | QQAEEALVAK | QELIDKLKEE | AEQHKIVMET | VPVLKAQADI | |
| 350: | YKADFQAERH | AREKLVERKE | LLQEQLEQLQ | REFNKLKVGC | HESARIEDMR | |
| 400: | KRHVETSQPP | LLPAPAHHSF | HLALSNQRRS | PPEEPPDFCC | PKCQYQAPDM | |
| 412: | DTLQIHVMEC | IE |
| 3D Structure: | N/A |
| UniGene: | Rn.214715 |
| Pfam: | PF11577 |
| String: | Q6TMG5 |
| SMR: | Q6TMG5 |
| KEGG: | rno:309295 |
| STRING: | 10116.ENSRNOP00000053114 |
| Uniprot: | Q6TMG5 |