| Gene name: | Ikbkg(Nemo); |
| Protein name: | NF-kappa-B essential modulator(NEMO); |
| Alternative: | NF-kappa-B essential modifier;IkB kinase-associated protein 1(IKKAP1;mFIP-3);Inhibitor of nuclear factor kappa-B kinase subunit gamma(I-kappa-B kinase subunit gamma;IKK-gamma;IKKG;IkB kinase subunit gamma); |
| Organism: | Mouse (Mus musculus). |
| Sub Unit: | Homodimer; disulfide-linked. Component of the I-kappa-B-kinase (IKK) core complex consisting of CHUK, IKBKB and IKBKG; probably four alpha/CHUK-beta/IKBKB dimers are associated with four gamma/IKBKG subunits. The IKK core complex seems to associate with regulatory or adapter proteins to form a IKK-signalosome holo-complex. The IKK complex associates with TERF2IP/RAP1, leading to promote IKK-mediated phosphorylation of RELA/p65. Part of a complex composed of NCOA2, NCOA3, CHUK/IKKA, IKBKB, IKBKG and CREBBP. Interacts with COPS3, CYLD, NALP2, TRPC4AP and LRDD. Interacts with ATM; the complex is exported from the nucleus. Interacts with TRAF6. Interacts with TANK; the interaction is enhanced by TBK1 and IKBKE. Part of a ternary complex consisting of TANK, IKBKB and IKBKG. Interacts with ZFAND5. Interacts with RIPK2. |
| Function: | Regulatory subunit of the IKK core complex which phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Also considered to be a mediator for TAX activation of NF-kappa-B. Could be implicated in NF-kappa-B-mediated protection from cytokine toxicity. |
| Subcellular Location: | Cytoplasm Nucleus |
| Sequence length: | 412 |
| Sequence: | |
| 50: | MNKHPWKNQL | SEMVQPSGGP | AEDQDMLGEE | SSLGKPAMLH | LPSEQGTPET | |
| 100: | LQRCLEENQE | LRDAIRQSNQ | MLRERCEELL | HFQVSQREEK | EFLMCKFQEA | |
| 150: | RKLVERLSLE | KLDLRSQREQ | ALKELEQLKK | CQQQMAEDKA | SVKAQVTSLL | |
| 200: | GELQESQSRL | EAATKDRQAL | EGRIRAVSEQ | VRQLESEREV | LQQQHSVQVD | |
| 250: | QLRMQNQSVE | AALRMERQAA | SEEKRKLAQL | QAAYHQLFQD | YDSHIKSSKG | |
| 300: | MQLEDLRQQL | QQAEEALVAK | QELIDKLKEE | AEQHKIVMET | VPVLKAQADI | |
| 350: | YKADFQAERH | AREKLVEKKE | YLQEQLEQLQ | REFNKLKVGC | HESARIEDMR | |
| 400: | KRHVETPQPP | LLPAPAHHSF | HLALSNQRRS | PPEEPPDFCC | PKCQYQAPDM | |
| 412: | DTLQIHVMEC | IE |
| 3D Structure: | N/A |
| KEGG: | mmu:16151 |
| Pfam: | PF11577 |
| STRING: | 10090.ENSMUSP00000004330 |
| SMR: | O88522 |
| String: | O88522 |
| UniGene: | Mm.12967 |
| Uniprot: | O88522 |