| Gene name: | IKBKG(FIP3;NEMO); |
| Protein name: | NF-kappa-B essential modulator(NEMO); |
| Alternative: | NF-kappa-B essential modifier;Inhibitor of nuclear factor kappa-B kinase subunit gamma(I-kappa-B kinase subunit gamma;IKK-gamma;IKKG;IkB kinase subunit gamma);FIP-3;IkB kinase-associated protein 1(IKKAP1); |
| Organism: | Human (Homo sapiens). |
| Sub Unit: | Homodimer; disulfide-linked. Component of the I-kappa-B-kinase (IKK) core complex consisting of CHUK, IKBKB and IKBKG; probably four alpha/CHUK-beta/IKBKB dimers are associated with four gamma/IKBKG subunits. The IKK core complex seems to associate with regulatory or adapter proteins to form a IKK-signalosome holo-complex. The IKK complex associates with TERF2IP/RAP1, leading to promote IKK-mediated phosphorylation of RELA/p65. Part of a complex composed of NCOA2, NCOA3, CHUK/IKKA, IKBKB, IKBKG and CREBBP. Interacts with COPS3, CYLD, NALP2, TRPC4AP and LRDD. Interacts with ATM; the complex is exported from the nucleus. Interacts with TRAF6. Interacts with HTLV-1 Tax oncoprotein; the interaction activates IKBKG. Interacts with TANK; the interaction is enhanced by IKBKE and TBK1. Part of a ternary complex consisting of TANK, IKBKB and IKBKG. Interacts with ZFAND5. Interacts with RIPK2. |
| Function: | Regulatory subunit of the IKK core complex which phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Also considered to be a mediator for TAX activation of NF-kappa-B. Could be implicated in NF-kappa-B-mediated protection from cytokine toxicity (By similarity). Essential for viral activation of IRF3. |
| Subcellular Location: | Cytoplasm Nucleus Sumoylated NEMO accumulates in the nucleus in response to genotoxic stress. |
| Sequence length: | 419 |
| Sequence: | |
| 50: | MNRHLWKSQL | CEMVQPSGGP | AADQDVLGEE | SPLGKPAMLH | LPSEQGAPET | |
| 100: | LQRCLEENQE | LRDAIRQSNQ | ILRERCEELL | HFQASQREEK | EFLMCKFQEA | |
| 150: | RKLVERLGLE | KLDLKRQKEQ | ALREVEHLKR | CQQQMAEDKA | SVKAQVTSLL | |
| 200: | GELQESQSRL | EAATKECQAL | EGRARAASEQ | ARQLESEREA | LQQQHSVQVD | |
| 250: | QLRMQGQSVE | AALRMERQAA | SEEKRKLAQL | QVAYHQLFQE | YDNHIKSSVV | |
| 300: | GSERKRGMQL | EDLKQQLQQA | EEALVAKQEV | IDKLKEEAEQ | HKIVMETVPV | |
| 350: | LKAQADIYKA | DFQAERQARE | KLAEKKELLQ | EQLEQLQREY | SKLKASCQES | |
| 400: | ARIEDMRKRH | VEVSQAPLPP | APAYLSSPLA | LPSQRRSPPE | EPPDFCCPKC | |
| 419: | QYQAPDMDTL | QIHVMECIE |
| 3D Structure: | N/A |
| Pfam: | PF11577 |
| SMR: | Q9Y6K9 |
| String: | Q9Y6K9 |
| MIM: | 300248 |
| UniGene: | Hs.43505 |
| KEGG: | hsa:8517 |
| STRING: | 9606.ENSP00000358622 |
| Uniprot: | Q9Y6K9 |