| Gene name: | SCG5(SGNE1); |
| Protein name: | Neuroendocrine protein 7B2; |
| Alternative: | Secretory granule endocrine protein I;Secretogranin-5;Pituitary polypeptide;Secretogranin V; |
| Organism: | Human (Homo sapiens). |
| Sub Unit: | Interacts with PCSK2/PC2 early in the secretory pathway. Dissociation occurs at later stages. |
| Function: | Acts as a molecular chaperone for PCSK2/PC2, preventing its premature activation in the regulated secretory pathway. Binds to inactive PCSK2 in the endoplasmic reticulum and facilitates its transport from there to later compartments of the secretory pathway where it is proteolytically matured and activated. Also required for cleavage of PCSK2 but does not appear to be involved in its folding. Plays a role in regulating pituitary hormone secretion. The C-terminal peptide inhibits PCSK2 in vitro. |
| Subcellular Location: | Secreted Neuroendocrine and endocrine secretory granules. |
| Sequence length: | 212 |
| Sequence: | |
| 50: | MVSRMVSTML | SGLLFWLASG | WTPAFAYSPR | TPDRVSEADI | QRLLHGVMEQ | |
| 100: | LGIARPRVEY | PAHQAMNLVG | PQSIEGGAHE | GLQHLGPFGN | IPNIVAELTG | |
| 150: | DNIPKDFSED | QGYPDPPNPC | PVGKTADDGC | LENTPDTAEF | SREFQLHQHL | |
| 200: | FDPEHDYPGL | GKWNKKLLYE | KMKGGERRKR | RSVNPYLQGQ | RLDNVVAKKS | |
| 212: | VPHFSDEDKD | PE |
| 3D Structure: | N/A |
| MIM: | 173120 |
| UniGene: | Hs.156540 |
| KEGG: | hsa:6447 |
| STRING: | 9606.ENSP00000300175 |
| Pfam: | PF05281 |
| String: | P05408 |
| Uniprot: | P05408 |