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ELISA Kit FOR Thyrotropin receptor

B9855r
Data Sheet

Description

Gene name:Tshr;
Protein name:Thyrotropin receptor;
Alternative: Thyroid-stimulating hormone receptor(TSH-R);
Organism:Rat (Rattus norvegicus).

General Annotation

Sub Unit:Interacts (via the PDZ-binding motif) with SCRIB; regulates TSHR trafficking and function.
Function:Receptor for thyrothropin. Plays a central role in controlling thyroid cell metabolism. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Also acts as a receptor for thyrostimulin (GPA2+GPB5).
Subcellular Location:Cell membrane Multi-pass membrane protein

Protein Attributes:

Sequence length:764
Sequence:
50:MRPGSLLQLT | LLLALPRSLW | GRGCTSPPCE | CHQEDDFRVT | CKELHQIPSL | 
100:PPSTQTLKLI | ETHLKTIPSL | AFSSLPNISR | IYLSIDATLQ | RLEPHSFYNL | 
150:SKMTHIEIRN | TRSLTYIDPD | ALTELPLLKF | LGIFNTGLRI | FPDLTKIYST | 
200:DVFFILEITD | NPYMTSVPEN | AFQGLCNETL | TLKLYNNGFT | SIQGHAFNGT | 
250:KLDAVYLNKN | KYLTAIDKDA | FGGVYSGPTL | LDVSSTSVTA | LPSKGLEHLK | 
300:ELIAKNTWTL | KKLPLSLSFL | HLTRADLSYP | SHCCAFKNQK | KIRGILESLM | 
350:CNESSIRNLR | QRKSVNVMRG | PVYQEYEEGL | GDNHVGYKQN | SKFQEGPSNS | 
400:HYYVFFEEQE | DEIIGFGQEL | KNPQEETLQA | FDSHYDYTVC | GDNEDMVCTP | 
450:KSDEFNPCED | IMGYKFLRIV | VWFVSPMALL | GNVFVLFVLL | TSHYKLTVPR | 
500:FLMCNLAFAD | FCMGVYLLLI | ASVDLYTHTE | YYNHAIDWQT | GPGCNTAGFF | 
550:TVFASELSVY | TLTVITLERW | YAITFAMRLD | RKIRLRHAYT | IMAGGWVSCF | 
600:LLALLPMVGI | SSYAKVSICL | PMDTDTPLAL | AYIALVLLLN | VVAFVIVCSC | 
650:YVKIYITVRN | PQYNPRDKDT | KIAKRMAVLI | FTDFMCMAPI | SFYALSALMN | 
700:KPLITVTNSG | VLLVLFYPLN | SCANPFLYAI | FTKAFQRDVF | ILLSKFGLCK | 
750:HQAQAYQAQR | VCPNNNTGIQ | IQKIPQDTRQ | SLPNVQDTYE | PLGSSHLTPK | 
764:LQGRISEEYT | QTAL
3D Structure:N/A

Related Databases

STRING:10116.ENSRNOP00000005671
UniGene:Rn.87913
Pfam:PF00001
KEGG:rno:25360
String:P21463
Uniprot:P21463

References