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ELISA Kit FOR Thyrotropin receptor

B9855m
Data Sheet

Description

Gene name:Tshr;
Protein name:Thyrotropin receptor;
Alternative: Thyroid-stimulating hormone receptor(TSH-R);
Organism:Mouse (Mus musculus).

General Annotation

Sub Unit:Interacts (via the PDZ-binding motif) with SCRIB; regulates TSHR trafficking and function.
Function:Receptor for thyrothropin. Plays a central role in controlling thyroid cell metabolism. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Also acts as a receptor for thyrostimulin (GPA2+GPB5).
Subcellular Location:Cell membrane Multi-pass membrane protein

Protein Attributes:

Sequence length:764
Sequence:
50:MRPGSLLLLV | LLLALSRSLR | GKECASPPCE | CHQEDDFRVT | CKELHRIPSL | 
100:PPSTQTLKLI | ETHLKTIPSL | AFSSLPNISR | IYLSIDATLQ | RLEPHSFYNL | 
150:SKMTHIEIRN | TRSLTYIDPD | ALTELPLLKF | LGIFNTGLRI | FPDLTKIYST | 
200:DIFFILEITD | NPYMTSVPEN | AFQGLCNETL | TLKLYNNGFT | SVQGHAFNGT | 
250:KLDAVYLNKN | KYLTAIDNDA | FGGVYSGPTL | LDVSSTSVTA | LPSKGLEHLK | 
300:ELIAKDTWTL | KKLPLSLSFL | HLTRADLSYP | SHCCAFKNQK | KIRGILESLM | 
350:CNESSIRNLR | QRKSVNILRG | PIYQEYEEDP | GDNSVGYKQN | SKFQESPSNS | 
400:HYYVFFEEQE | DEVVGFGQEL | KNPQEETLQA | FESHYDYTVC | GDNEDMVCTP | 
450:KSDEFNPCED | IMGYRFLRIV | VWFVSLLALL | GNIFVLLILL | TSHYKLTVPR | 
500:FLMCNLAFAD | FCMGVYLLLI | ASVDLYTHSE | YYNHAIDWQT | GPGCNTAGFF | 
550:TVFASELSVY | TLTVITLERW | YAITFAMRLD | RKIRLRHAYT | IMAGGWVSCF | 
600:LLALLPMVGI | SSYAKVSICL | PMDTDTPLAL | AYIVLVLLLN | VVAFVVVCSC | 
650:YVKIYITVRN | PQYNPRDKDT | KIAKRMAVLI | FTDFMCMAPI | SFYALSALMN | 
700:KPLITVTNSK | ILLVLFYPLN | SCANPFLYAI | FTKAFQRDVF | ILLSKFGICK | 
750:RQAQAYQGQR | VCPNNSTGIQ | IQKIPQDTRQ | SLPNMQDTYE | LLGNSQLAPK | 
764:LQGQISEEYK | QTAL
3D Structure:N/A

Related Databases

UniGene:Mm.173847
KEGG:mmu:22095
SMR:P47750
String:P47750
Pfam:PF00001
Uniprot:P47750

References