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ELISA Kit FOR Thyrotropin receptor

B9855h
Data Sheet

Description

Gene name:TSHR(LGR3);
Protein name:Thyrotropin receptor;
Alternative: Thyroid-stimulating hormone receptor(TSH-R);
Organism:Human (Homo sapiens).

General Annotation

Sub Unit:Interacts (via the PDZ-binding motif) with SCRIB; regulates TSHR trafficking and function.
Function:Receptor for thyrothropin. Plays a central role in controlling thyroid cell metabolism. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Also acts as a receptor for thyrostimulin (GPA2+GPB5).
Subcellular Location:Cell membrane Multi-pass membrane protein

Protein Attributes:

Sequence length:764
Sequence:
50:MRPADLLQLV | LLLDLPRDLG | GMGCSSPPCE | CHQEEDFRVT | CKDIQRIPSL | 
100:PPSTQTLKLI | ETHLRTIPSH | AFSNLPNISR | IYVSIDVTLQ | QLESHSFYNL | 
150:SKVTHIEIRN | TRNLTYIDPD | ALKELPLLKF | LGIFNTGLKM | FPDLTKVYST | 
200:DIFFILEITD | NPYMTSIPVN | AFQGLCNETL | TLKLYNNGFT | SVQGYAFNGT | 
250:KLDAVYLNKN | KYLTVIDKDA | FGGVYSGPSL | LDVSQTSVTA | LPSKGLEHLK | 
300:ELIARNTWTL | KKLPLSLSFL | HLTRADLSYP | SHCCAFKNQK | KIRGILESLM | 
350:CNESSMQSLR | QRKSVNALNS | PLHQEYEENL | GDSIVGYKEK | SKFQDTHNNA | 
400:HYYVFFEEQE | DEIIGFGQEL | KNPQEETLQA | FDSHYDYTIC | GDSEDMVCTP | 
450:KSDEFNPCED | IMGYKFLRIV | VWFVSLLALL | GNVFVLLILL | TSHYKLNVPR | 
500:FLMCNLAFAD | FCMGMYLLLI | ASVDLYTHSE | YYNHAIDWQT | GPGCNTAGFF | 
550:TVFASELSVY | TLTVITLERW | YAITFAMRLD | RKIRLRHACA | IMVGGWVCCF | 
600:LLALLPLVGI | SSYAKVSICL | PMDTETPLAL | AYIVFVLTLN | IVAFVIVCCC | 
650:YVKIYITVRN | PQYNPGDKDT | KIAKRMAVLI | FTDFICMAPI | SFYALSAILN | 
700:KPLITVSNSK | ILLVLFYPLN | SCANPFLYAI | FTKAFQRDVF | ILLSKFGICK | 
750:RQAQAYRGQR | VPPKNSTDIQ | VQKVTHDMRQ | GLHNMEDVYE | LIENSHLTPK | 
764:KQGQISEEYM | QTVL
3D Structure:N/A

Related Databases

KEGG:hsa:7253
STRING:9606.ENSP00000298171
UniGene:Hs.160411
String:P16473
SMR:P16473
Pfam:PF00001
MIM:275200
Uniprot:P16473

References