| Gene name: | Trib3(Nipk); |
| Protein name: | Tribbles homolog 3(TRB-3); |
| Alternative: | Neuronal cell death-inducible putative kinase; |
| Organism: | Rat (Rattus norvegicus). |
| Sub Unit: | Interacts with AKT1, AKT2, ATF4, MAP2K1 and MAP2K7. |
| Function: | Disrupts insulin signaling by binding directly to Akt kinases and blocking their activation. May bind directly to and mask the 'Thr-308' phosphorylation site in AKT1. Binds to ATF4 and inhibits its transcriptional activation activity. Interacts with the NF-kappa-B transactivator p65 RELA and inhibits its phosphorylation and thus its transcriptional activation activity. Interacts with MAPK kinases and regulates activation of MAP kinases. May play a role in programmed neuronal cell death but does not appear to affect non-neuronal cells. Does not display kinase activity. |
| Subcellular Location: | Nucleus |
| Sequence length: | 349 |
| Sequence: | |
| 50: | MRATSLAASA | DVPCRKKPLE | FDDNIDVECP | VLKRVRDEPE | PGPTPSLPPA | |
| 100: | SDLSPAVAPA | TRLGPYILLE | REQGNCTYRA | LHCPTGTEYT | CKVYPASEAQ | |
| 150: | AVLAPYARLP | THQHVARPTE | VLLGSQLLYT | FFTKTHGDLH | SLVRSRRGIP | |
| 200: | EPEAAALFRQ | MASAVAHCHK | HGLILRDLKL | RRFVFSNCER | TKLVLENLED | |
| 250: | ACVMTGPDDS | LWDKHACPAY | VGPEILSSRP | SYSGRAADVW | SLGVALFTML | |
| 300: | AGRYPFQDSE | PALLFGKIRR | GTFALPEGLS | ASARCLIRCL | LRREPSERLV | |
| 349: | ALGILLHPWL | REDCSQVSPP | RSDRREMDQV | VPDGPQLEEA | EEGEVGLYG |
| 3D Structure: | N/A |
| KEGG: | rno:246273 |
| UniGene: | Rn.22325 |
| String: | Q9WTQ6 |
| Pfam: | PF00069 |
| Uniprot: | Q9WTQ6 |