| Gene name: | Trib3(Nipk;Trb3); |
| Protein name: | Tribbles homolog 3(TRB-3); |
| Alternative: | Neuronal cell death-inducible putative kinase; |
| Organism: | Mouse (Mus musculus). |
| Sub Unit: | Interacts with AKT1, AKT2, ATF4, MAP2K1 and MAP2K7. |
| Function: | Disrupts insulin signaling by binding directly to Akt kinases and blocking their activation. May bind directly to and mask the 'Thr-308' phosphorylation site in AKT1. Binds to ATF4 and inhibits its transcriptional activation activity. Interacts with the NF-kappa-B transactivator p65 RELA and inhibits its phosphorylation and thus its transcriptional activation activity. Interacts with MAPK kinases and regulates activation of MAP kinases. May play a role in programmed neuronal cell death but does not appear to affect non-neuronal cells. Does not display kinase activity. |
| Subcellular Location: | Nucleus |
| Sequence length: | 354 |
| Sequence: | |
| 50: | MRATPLAASA | DVSCRKKPLE | FDDNIDAKCP | VLKRVRDEPE | PGPLPSLLPP | |
| 100: | SPPPASDLSP | AVAPATRLGP | YILLEREQGS | CSYRALHCPT | GTEYTCKVYP | |
| 150: | ASEAQAVLAP | YARLPTHQHV | ARPTEVLLGS | RLLYIFFTKT | HGDLHSLVRS | |
| 200: | RRGIPESEAA | GLFRQMASAV | AHCHKHGLVL | RDLKLRRFVF | SNCERTKLVL | |
| 250: | ENLEDACVMT | GSDDSLWDKH | ACPAYVGPEI | LSSRPSYSGK | AADVWSLGVA | |
| 300: | LFTMLAGRYP | FHDSEPVLLF | GKIRRGTFAL | PEGLSAPARC | LIRCLLRKEP | |
| 350: | SERLVALGIL | LHPWLREDHG | RVSPPQSDRR | EMDQVVPDGP | QLEEAEEGEV | |
| 354: | GLYG |
| 3D Structure: | N/A |
| KEGG: | mmu:228775 |
| SMR: | Q8K4K2 |
| String: | Q8K4K2 |
| Pfam: | PF00069 |
| UniGene: | Mm.276018 |
| Uniprot: | Q8K4K2 |