| Gene name: | TRIB3(C20orf97;NIPK;SKIP3;TRB3); |
| Protein name: | Tribbles homolog 3(TRB-3); |
| Alternative: | p65-interacting inhibitor of NF-kappa-B;Neuronal cell death-inducible putative kinase;SINK; |
| Organism: | Human (Homo sapiens). |
| Sub Unit: | Interacts with AKT1, AKT2, ATF4, MAP2K1 and MAP2K7. |
| Function: | Disrupts insulin signaling by binding directly to Akt kinases and blocking their activation. May bind directly to and mask the 'Thr-308' phosphorylation site in AKT1. Binds to ATF4 and inhibits its transcriptional activation activity. Interacts with the NF-kappa-B transactivator p65 RELA and inhibits its phosphorylation and thus its transcriptional activation activity. Interacts with MAPK kinases and regulates activation of MAP kinases. May play a role in programmed neuronal cell death but does not appear to affect non-neuronal cells. Does not display kinase activity. |
| Subcellular Location: | Nucleus |
| Sequence length: | 358 |
| Sequence: | |
| 50: | MRATPLAAPA | GSLSRKKRLE | LDDNLDTERP | VQKRARSGPQ | PRLPPCLLPL | |
| 100: | SPPTAPDRAT | AVATASRLGP | YVLLEPEEGG | RAYQALHCPT | GTEYTCKVYP | |
| 150: | VQEALAVLEP | YARLPPHKHV | ARPTEVLAGT | QLLYAFFTRT | HGDMHSLVRS | |
| 200: | RHRIPEPEAA | VLFRQMATAL | AHCHQHGLVL | RDLKLCRFVF | ADRERKKLVL | |
| 250: | ENLEDSCVLT | GPDDSLWDKH | ACPAYVGPEI | LSSRASYSGK | AADVWSLGVA | |
| 300: | LFTMLAGHYP | FQDSEPVLLF | GKIRRGAYAL | PAGLSAPARC | LVRCLLRREP | |
| 350: | AERLTATGIL | LHPWLRQDPM | PLAPTRSHLW | EAAQVVPDGL | GLDEAREEEG | |
| 358: | DREVVLYG |
| 3D Structure: | N/A |
| STRING: | 9606.ENSP00000217233 |
| KEGG: | hsa:57761 |
| SMR: | Q96RU7 |
| MIM: | 607898 |
| String: | Q96RU7 |
| UniGene: | Hs.516826 |
| Pfam: | PF00069 |
| Uniprot: | Q96RU7 |