| Gene name: | TRIB3; |
| Protein name: | Tribbles homolog 3(TRB-3); |
| Alternative: | |
| Organism: | Bovine (Bos taurus). |
| Sub Unit: | Interacts with AKT1, AKT2, ATF4, MAP2K1 and MAP2K7. |
| Function: | Disrupts insulin signaling by binding directly to Akt kinases and blocking their activation. May bind directly to and mask the 'Thr-308' phosphorylation site in AKT1. Binds to ATF4 and inhibits its transcriptional activation activity. Interacts with the NF-kappa-B transactivator p65 RELA and inhibits its phosphorylation and thus its transcriptional activation activity. Interacts with MAPK kinases and regulates activation of MAP kinases. May play a role in programmed neuronal cell death but does not appear to affect non-neuronal cells. Does not display kinase activity. |
| Subcellular Location: | Nucleus |
| Sequence length: | 357 |
| Sequence: | |
| 50: | MRASPLAVPA | NAPSRKKRLE | LDDDLDTECP | SQKQARSGPQ | PRLPSCPLTL | |
| 100: | NPPPAPVHAP | DVTTPSRLGP | YVLLEPEEGS | RTYRALHCPT | GTEYICKVYP | |
| 150: | ACERLAVLEP | YWRLPHHGHV | ARPAEVLAGT | QLLYAFFLRP | HGDMHSLVRR | |
| 200: | RRRLPEPEAA | ALFRQMAAAL | AHCHQHGLVL | RDLKLRRFVF | TDRERTKLVL | |
| 250: | ENLEDACVLT | GPDDSLWDKH | ACPAYVGPEI | LSSRASYSGK | AADVWSLGVA | |
| 300: | LFTMLAGHYP | FQDSEPALLF | GKIRRGAFAL | PEGLSAPARC | LVRCLLRREP | |
| 350: | TERLTASGIL | LHPWLRENAI | PAALPRSRHC | EADQVVPEGP | GLEEAEEEGE | |
| 357: | RDMGLYG |
| 3D Structure: | N/A |
| String: | Q0VCE3 |
| KEGG: | bta:538465 |
| UniGene: | Bt.45499 |
| Pfam: | PF00069 |
| STRING: | 9913.ENSBTAP00000022616 |
| Uniprot: | Q0VCE3 |