| Gene name: | Tnfaip3(Tnfip3); |
| Protein name: | Tumor necrosis factor alpha-induced protein 3(TNF alpha-induced protein 3); |
| Alternative: | Putative DNA-binding protein A20;Zinc finger protein A20; |
| Organism: | Mouse (Mus musculus). |
| Sub Unit: | Homodimer. Interacts with NAF1, TAX1BP1 and TRAF2. Interacts with RNF11, ITCH and TAX1BP1 only after TNF stimulation; these interaction are transient and they are lost after 1 hour of stimulation with TNF. |
| Function: | Ubiquitin-editing enzyme that contains both ubiquitin ligase and deubiquitinase activities. Essential component of a ubiquitin-editing protein complex, comprising also RNF11, ITCH and TAX1BP1, that ensures the transient nature of inflammatory signaling pathways. Upon TNF stimulation, deubiquitinates 'Lys-63'-polyubiquitin chains on RIPK1 and catalyzes the formation of 'Lys-48'-polyubiquitin chains. This leads to RIPK1 proteasomal degradation and consequently termination of the TNF- or LPS-mediated activation of NF-kappa-B. In vitro able to deubiquitinate both 'Lys-48'- and 'Lys-63' polyubiquitin chains. Inhibitor of programmed cell death. Has a role in the function of the lymphoid system. |
| Subcellular Location: | Cytoplasm Nucleus |
| Sequence length: | 775 |
| Sequence: | |
| 50: | MAEQLLPQAL | YLSNMRKAVK | IRERTPEDIF | KPTNGIIYHF | KTMHRYTLEM | |
| 100: | FRTCQFCPQF | REIIHKALID | RSVQASLESQ | KKLNWCREVR | KLVALKTNGD | |
| 150: | GNCLMHAACQ | YMWGVQDTDL | VLRKALCSTL | KETDTRNFKF | RWQLESLKSQ | |
| 200: | EFVETGLCYD | TRNWNDEWDN | LVKMASADTP | AARSGLQYNS | LEEIHIFVLS | |
| 250: | NILRRPIIVI | SDKMLRSLES | GSNFAPLKVG | GIYLPLHWPA | QECYRYPIVL | |
| 300: | GYDSQHFVPL | VTLKDSGPEL | RAVPLVNRDR | GRFEDLKVHF | LTDPENEMKE | |
| 350: | KLLKEYLIVM | EIPVQGWDHG | TTHLINAAKL | DEANLPKEIN | LVDDYFELVQ | |
| 400: | HEYKKWQENS | DQARRAAHAQ | NPLEPSTPQL | SLMDIKCETP | NCPFFMSVNT | |
| 450: | QPLCHECSER | RQKNQSKLPK | LNSKLGPEGL | PGVGLGSSNW | SPEETAGGPH | |
| 500: | SAPPTAPSLF | LFSETTAMKC | RSPGCPFTLN | VQHNGFCERC | HARQINASHT | |
| 550: | ADPGKCQACL | QDVTRTFNGI | CSTCFKRTTA | EPSSSLTSSI | PASCHQRSKS | |
| 600: | DPSQLIQSLT | PHSCHRTGNV | SPSGCLSQAA | RTPGDRAGTS | KCRKAGCMYF | |
| 650: | GTPENKGFCT | LCFIEYRENK | QSVTASEKAG | SPAPRFQNNV | PCLGRECGTL | |
| 700: | GSTMFEGYCQ | KCFIEAQNQR | FHEARRTEEQ | LRSSQHRDMP | RTTQVASRLK | |
| 750: | CARASCKNIL | ACRSEELCME | CQHLSQRVGS | VAHRGEPTPE | EPPKQRCRAP | |
| 775: | ACDHFGNAKC | NGYCNECYQF | KQMYG |
| 3D Structure: | N/A |
| String: | Q60769 |
| KEGG: | mmu:21929 |
| STRING: | 10090.ENSMUSP00000101167 |
| Pfam: | PF02338 |
| SMR: | Q60769 |
| UniGene: | Mm.116683 |
| Uniprot: | Q60769 |