| Gene name: | TNFAIP3(OTUD7C); |
| Protein name: | Tumor necrosis factor alpha-induced protein 3(TNF alpha-induced protein 3); |
| Alternative: | Zinc finger protein A20;OTU domain-containing protein 7C;Putative DNA-binding protein A20; |
| Organism: | Human (Homo sapiens). |
| Sub Unit: | Homodimer. Interacts with NAF1, TAX1BP1 and TRAF2. Interacts with RNF11, ITCH and TAX1BP1 only after TNF stimulation; these interaction are transient and they are lost after 1 hour of stimulation with TNF. |
| Function: | Ubiquitin-editing enzyme that contains both ubiquitin ligase and deubiquitinase activities. Essential component of a ubiquitin-editing protein complex, comprising also RNF11, ITCH and TAX1BP1, that ensures the transient nature of inflammatory signaling pathways. Upon TNF stimulation, deubiquitinates 'Lys-63'-polyubiquitin chains on RIPK1 and catalyzes the formation of 'Lys-48'-polyubiquitin chains. This leads to RIPK1 proteasomal degradation and consequently termination of the TNF- or LPS-mediated activation of NF-kappa-B. In vitro able to deubiquitinate both 'Lys-48'- and 'Lys-63' polyubiquitin chains. Inhibitor of programmed cell death. Has a role in the function of the lymphoid system. |
| Subcellular Location: | Cytoplasm Nucleus |
| Sequence length: | 790 |
| Sequence: | |
| 50: | MAEQVLPQAL | YLSNMRKAVK | IRERTPEDIF | KPTNGIIHHF | KTMHRYTLEM | |
| 100: | FRTCQFCPQF | REIIHKALID | RNIQATLESQ | KKLNWCREVR | KLVALKTNGD | |
| 150: | GNCLMHATSQ | YMWGVQDTDL | VLRKALFSTL | KETDTRNFKF | RWQLESLKSQ | |
| 200: | EFVETGLCYD | TRNWNDEWDN | LIKMASTDTP | MARSGLQYNS | LEEIHIFVLC | |
| 250: | NILRRPIIVI | SDKMLRSLES | GSNFAPLKVG | GIYLPLHWPA | QECYRYPIVL | |
| 300: | GYDSHHFVPL | VTLKDSGPEI | RAVPLVNRDR | GRFEDLKVHF | LTDPENEMKE | |
| 350: | KLLKEYLMVI | EIPVQGWDHG | TTHLINAAKL | DEANLPKEIN | LVDDYFELVQ | |
| 400: | HEYKKWQENS | EQGRREGHAQ | NPMEPSVPQL | SLMDVKCETP | NCPFFMSVNT | |
| 450: | QPLCHECSER | RQKNQNKLPK | LNSKPGPEGL | PGMALGASRG | EAYEPLAWNP | |
| 500: | EESTGGPHSA | PPTAPSPFLF | SETTAMKCRS | PGCPFTLNVQ | HNGFCERCHN | |
| 550: | ARQLHASHAP | DHTRHLDPGK | CQACLQDVTR | TFNGICSTCF | KRTTAEASSS | |
| 600: | LSTSLPPSCH | QRSKSDPSRL | VRSPSPHSCH | RAGNDAPAGC | LSQAARTPGD | |
| 650: | RTGTSKCRKA | GCVYFGTPEN | KGFCTLCFIE | YRENKHFAAA | SGKVSPTASR | |
| 700: | FQNTIPCLGR | ECGTLGSTMF | EGYCQKCFIE | AQNQRFHEAK | RTEEQLRSSQ | |
| 750: | RRDVPRTTQS | TSRPKCARAS | CKNILACRSE | ELCMECQHPN | QRMGPGAHRG | |
| 790: | EPAPEDPPKQ | RCRAPACDHF | GNAKCNGYCN | ECFQFKQMYG | |
| 3D Structure: | N/A |
| MIM: | 191163 |
| Pfam: | PF02338 |
| STRING: | 9606.ENSP00000237289 |
| KEGG: | hsa:7128 |
| String: | P21580 |
| SMR: | P21580 |
| UniGene: | Hs.211600 |
| Uniprot: | P21580 |