| Gene name: | CXCR1(CMKAR1;IL8RA); |
| Protein name:Alternative: CD: | C-X-C chemokine receptor type 1(CXC-R1;CXCR-1); IL-8 receptor type 1;CDw128a;High affinity interleukin-8 receptor A(IL-8R A); CD181; |
| Organism: | Human (Homo sapiens). |
| Sub Unit: | N/A |
| Function: | Receptor to interleukin-8, which is a powerful neutrophils chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activate a phosphatidylinositol-calcium second messenger system. This receptor binds to IL-8 with a high affinity and to MGSA (GRO) with a low affinity. |
| Subcellular Location: | Cell membrane Multi-pass membrane protein |
| Sequence length: | 350 |
| Sequence: | |
| 50: | MSNITDPQMW | DFDDLNFTGM | PPADEDYSPC | MLETETLNKY | VVIIAYALVF | |
| 100: | LLSLLGNSLV | MLVILYSRVG | RSVTDVYLLN | LALADLLFAL | TLPIWAASKV | |
| 150: | NGWIFGTFLC | KVVSLLKEVN | FYSGILLLAC | ISVDRYLAIV | HATRTLTQKR | |
| 200: | HLVKFVCLGC | WGLSMNLSLP | FFLFRQAYHP | NNSSPVCYEV | LGNDTAKWRM | |
| 250: | VLRILPHTFG | FIVPLFVMLF | CYGFTLRTLF | KAHMGQKHRA | MRVIFAVVLI | |
| 300: | FLLCWLPYNL | VLLADTLMRT | QVIQESCERR | NNIGRALDAT | EILGFLHSCL | |
| 350: | |
| 3D Structure: | N/A |
| SMR: | P25024 |
| MIM: | 146929 |
| UniGene: | Hs.194778 |
| KEGG: | hsa:3577 |
| Pfam: | PF00001 |
| String: | P25024 |
| Uniprot: | P25024 |