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ELISA Kit FOR Bone morphogenetic protein receptor type-2

B0016m
Data Sheet

Description

Gene name:Bmpr2;
Protein name:Bone morphogenetic protein receptor type-2(BMP type-2 receptor;BMPR-2);
Alternative: BRK-3;Bone morphogenetic protein receptor type II(BMP type II receptor;BMPR-II);
Organism:Mouse (Mus musculus).

General Annotation

Sub Unit:N/A
Function:On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Binds to BMP-7, BMP-2 and, less efficiently, BMP-4. Binding is weak but enhanced by the presence of type I receptors for BMPs.
Subcellular Location:Membrane Single-pass type I membrane protein

Protein Attributes:

Sequence length:1038
Sequence:
50:MTSSLHRPFR | VPWLLWAVLL | VSTTAASQNQ | ERLCAFKDPY | QQDLGIGESR | 
100:ISHENGTILC | SKGSTCYGLW | EKSKGDINLV | KQGCWSHIGD | PQECHYEECV | 
150:VTTTPPSIQN | GTYRFCCCST | DLCNVNFTEN | FPPPDTTPLS | PPHSFNRDET | 
200:IIIALASVSV | LAVLIVALCF | GYRMLTGDRK | QGLHSMNMME | AAAAEPSLDL | 
250:DNLKLLELIG | RGRYGAVYKG | SLDERPVAVK | VFSFANRQNF | INEKNIYRVP | 
300:LMEHDNIARF | IVGDERLTAD | GRMEYLLVME | YYPNGSLCKY | LSLHTSDWVS | 
350:SCRLAHSVTR | GLAYLHTELP | RGDHYKPAIS | HRDLNSRNVL | VKNDGACVIS | 
400:DFGLSMRLTG | NRLVRPGEED | NAAISEVGTI | RYMAPEVLEG | AVNLRDCESA | 
450:LKQVDMYALG | LIYWEVFMRC | TDLFPGESVP | DYQMAFQTEV | GNHPTFEDMQ | 
500:VLVSREKQRP | KFPEAWKENS | LAVRSLKETI | EDCWDQDAEA | RLTAQCAEER | 
550:MAELMMIWER | NKSVSPTVNP | MSTAMQNERN | LSHNRRVPKI | GPYPDYSSSS | 
600:YIEDSIHHTD | SIVKNISSEH | SMSSTPLTIG | EKNRNSINYE | RQQAQARIPS | 
650:PETSVTSLST | NTTTTNTTGL | TPSTGMTTIS | EMPYPDETHL | HATNVAQSIG | 
700:PTPVCLQLTE | EDLETNKLDP | KEVDKNLKES | SDENLMEHSL | KQFSGPDPLS | 
750:STSSSLLYPL | IKLAVEVTGQ | QDFTQAANGQ | ACLIPDVPPA | QIYPLPKQQN | 
800:LPKRPTSLPL | NTKNSTKEPR | LKFGNKHKSN | LKQVETGVAK | MNTINAAEPH | 
850:VVTVTMNGVA | GRSHNVNSHA | ATTQYANGAV | PAGQAANIVA | HRSQEMLQNQ | 
900:FIGEDTRLNI | NSSPDEHEPL | LRREQQAGHD | EGVLDRLVDR | RERPLEGGRT | 
950:NSNNNNSNPC | SEQDILTQGV | TSTAADPGPS | KPRRAQRPNS | LDLSATNILD | 
1000:GSSIQIGEST | QDGKSGSGEK | IKRRVKTPYS | LKRWRPSTWV | ISTEPLDCEV | 
1038:NNNGSDRAVH | SKSSTAVYLA | EGGTATTTVS | KDIGMNCL
3D Structure:N/A

Related Databases

Pfam:PF01064
String:O35607
UniGene:Mm.391654
SMR:O35607
KEGG:mmu:12168
Uniprot:O35607

References