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ELISA Kit FOR Bone morphogenetic protein receptor type-2

B0016h
Data Sheet

Description

Gene name:BMPR2(PPH1);
Protein name:Bone morphogenetic protein receptor type-2(BMP type-2 receptor;BMPR-2);
Alternative: Bone morphogenetic protein receptor type II(BMP type II receptor;BMPR-II);
Organism:Human (Homo sapiens).

General Annotation

Sub Unit:N/A
Function:On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Binds to BMP-7, BMP-2 and, less efficiently, BMP-4. Binding is weak but enhanced by the presence of type I receptors for BMPs.
Subcellular Location:Membrane Single-pass type I membrane protein

Protein Attributes:

Sequence length:1038
Sequence:
50:MTSSLQRPWR | VPWLPWTILL | VSTAAASQNQ | ERLCAFKDPY | QQDLGIGESR | 
100:ISHENGTILC | SKGSTCYGLW | EKSKGDINLV | KQGCWSHIGD | PQECHYEECV | 
150:VTTTPPSIQN | GTYRFCCCST | DLCNVNFTEN | FPPPDTTPLS | PPHSFNRDET | 
200:IIIALASVSV | LAVLIVALCF | GYRMLTGDRK | QGLHSMNMME | AAASEPSLDL | 
250:DNLKLLELIG | RGRYGAVYKG | SLDERPVAVK | VFSFANRQNF | INEKNIYRVP | 
300:LMEHDNIARF | IVGDERVTAD | GRMEYLLVME | YYPNGSLCKY | LSLHTSDWVS | 
350:SCRLAHSVTR | GLAYLHTELP | RGDHYKPAIS | HRDLNSRNVL | VKNDGTCVIS | 
400:DFGLSMRLTG | NRLVRPGEED | NAAISEVGTI | RYMAPEVLEG | AVNLRDCESA | 
450:LKQVDMYALG | LIYWEIFMRC | TDLFPGESVP | EYQMAFQTEV | GNHPTFEDMQ | 
500:VLVSREKQRP | KFPEAWKENS | LAVRSLKETI | EDCWDQDAEA | RLTAQCAEER | 
550:MAELMMIWER | NKSVSPTVNP | MSTAMQNERN | LSHNRRVPKI | GPYPDYSSSS | 
600:YIEDSIHHTD | SIVKNISSEH | SMSSTPLTIG | EKNRNSINYE | RQQAQARIPS | 
650:PETSVTSLST | NTTTTNTTGL | TPSTGMTTIS | EMPYPDETNL | HTTNVAQSIG | 
700:PTPVCLQLTE | EDLETNKLDP | KEVDKNLKES | SDENLMEHSL | KQFSGPDPLS | 
750:STSSSLLYPL | IKLAVEATGQ | QDFTQTANGQ | ACLIPDVLPT | QIYPLPKQQN | 
800:LPKRPTSLPL | NTKNSTKEPR | LKFGSKHKSN | LKQVETGVAK | MNTINAAEPH | 
850:VVTVTMNGVA | GRNHSVNSHA | ATTQYANGTV | LSGQTTNIVT | HRAQEMLQNQ | 
900:FIGEDTRLNI | NSSPDEHEPL | LRREQQAGHD | EGVLDRLVDR | RERPLEGGRT | 
950:NSNNNNSNPC | SEQDVLAQGV | PSTAADPGPS | KPRRAQRPNS | LDLSATNVLD | 
1000:GSSIQIGEST | QDGKSGSGEK | IKKRVKTPYS | LKRWRPSTWV | ISTESLDCEV | 
1038:NNNGSNRAVH | SKSSTAVYLA | EGGTATTMVS | KDIGMNCL
3D Structure:N/A

Related Databases

KEGG:hsa:659
STRING:9606.ENSP00000363708
MIM:178600
Pfam:PF01064
UniGene:Hs.471119
String:Q13873
SMR:Q13873
Uniprot:Q13873

References