Gene name: | Ctgf(Ccn2;Fisp-12;Fisp12;Hcs24); |
Protein name: | Connective tissue growth factor; |
Alternative: | Protein FISP-12;CCN family member 2;Hypertrophic chondrocyte-specific protein 24; |
Organism: | Mouse (Mus musculus). |
Sub Unit: | Monomer. |
Function: | Major connective tissue mitoattractant secreted by vascular endothelial cells. Promotes proliferation and differentiation of chondrocytes (By similarity). Mediates heparin-and divalent cation-dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells (By similarity). Enhances fibroblast growth factor-induced DNA synthesis. |
Subcellular Location: | Secreted extracellular space extracellular matrix Secreted |
Sequence length: | 348 |
Sequence: | |
50: | MLASVAGPIS | LALVLLALCT | RPATGQDCSA | QCQCAAEAAP | HCPAGVSLVL | |
100: | DGCGCCRVCA | KQLGELCTER | DPCDPHKGLF | CDFGSPANRK | IGVCTAKDGA | |
150: | PCVFGGSVYR | SGESFQSSCK | YQCTCLDGAV | GCVPLCSMDV | RLPSPDCPFP | |
200: | RRVKLPGKCC | EEWVCDEPKD | RTAVGPALAA | YRLEDTFGPD | PTMMRANCLV | |
250: | QTTEWSACSK | TCGMGISTRV | TNDNTFCRLE | KQSRLCMVRP | CEADLEENIK | |
300: | KGKKCIRTPK | IAKPVKFELS | GCTSVKTYRA | KFCGVCTDGR | CCTPHRTTTL | |
348: | PVEFKCPDGE | IMKKNMMFIK | TCACHYNCPG | DNDIFESLYY | RKMYGDMA |
3D Structure: | N/A |
SMR: | P29268 |
String: | P29268 |
STRING: | 10090.ENSMUSP00000020171 |
Pfam: | PF00007 |
UniGene: | Mm.390287 |
KEGG: | mmu:14219 |
Uniprot: | P29268 |