| Gene name: | CTGF(CCN2;HCS24;IGFBP8); |
| Protein name: | Connective tissue growth factor; |
| Alternative: | Insulin-like growth factor-binding protein 8(IBP-8;IGF-binding protein 8;IGFBP-8);CCN family member 2;Hypertrophic chondrocyte-specific protein 24; |
| Organism: | Human (Homo sapiens). |
| Sub Unit: | Monomer. |
| Function: | Major connective tissue mitoattractant secreted by vascular endothelial cells. Promotes proliferation and differentiation of chondrocytes. Mediates heparin- and divalent cation-dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells. Enhances fibroblast growth factor-induced DNA synthesis. |
| Subcellular Location: | Secreted extracellular space extracellular matrix Secreted |
| Sequence length: | 349 |
| Sequence: | |
| 50: | MTAASMGPVR | VAFVVLLALC | SRPAVGQNCS | GPCRCPDEPA | PRCPAGVSLV | |
| 100: | LDGCGCCRVC | AKQLGELCTE | RDPCDPHKGL | FCHFGSPANR | KIGVCTAKDG | |
| 150: | APCIFGGTVY | RSGESFQSSC | KYQCTCLDGA | VGCMPLCSMD | VRLPSPDCPF | |
| 200: | PRRVKLPGKC | CEEWVCDEPK | DQTVVGPALA | AYRLEDTFGP | DPTMIRANCL | |
| 250: | VQTTEWSACS | KTCGMGISTR | VTNDNASCRL | EKQSRLCMVR | PCEADLEENI | |
| 300: | KKGKKCIRTP | KISKPIKFEL | SGCTSMKTYR | AKFCGVCTDG | RCCTPHRTTT | |
| 349: | LPVEFKCPDG | EVMKKNMMFI | KTCACHYNCP | GDNDIFESLY | YRKMYGDMA |
| 3D Structure: | N/A |
| SMR: | P29279 |
| STRING: | 9606.ENSP00000356954 |
| MIM: | 121009 |
| UniGene: | Hs.410037 |
| Pfam: | PF00007 |
| String: | P29279 |
| KEGG: | hsa:1490 |
| Uniprot: | P29279 |