| Gene name: | Angpt2(Agpt2); |
| Protein name: | Angiopoietin-2(ANG-2); |
| Alternative: | |
| Organism: | Rat (Rattus norvegicus). |
| Sub Unit: | N/A |
| Function: | Can induce tyrosine phosphorylation of TIE2. Binds to Binds to TIE2 receptor and counteracts blood vessel maturation/stability mediated by angiopoietin-1. Its function may be context-dependent. In the absence of angiogenic inducers, such as VEGF, ANG2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal. |
| Subcellular Location: | Secreted |
| Sequence length: | 496 |
| Sequence: | |
| 50: | MWQIVFLTFG | CDLVLASAYN | NFRKSVDSTG | RRQYQVQNGP | CSYTFLLPET | |
| 100: | DSCRSSSSPY | MSNAVQRDAP | LDYDDSVQRL | QVLENILENN | TQWLMKLENY | |
| 150: | IQDNMKKEMV | EIQQNVVQNQ | TAVMIEIGTS | LLNQTAAQTR | KLTDVEAQVL | |
| 200: | NQTTRLELQL | LQHSISTNKL | EKQILDQTSE | INKLQDKNSF | LEKKVLDMED | |
| 250: | KHSVQLQSMK | EQKDQLQVLV | SKQSSVIDEL | EKKLVTATVN | NSVLQKQQHD | |
| 300: | LMETVNSLLT | MMSSPDYKSS | VAVPKEEKTT | FRDCAEIFKS | GLTTSGIYTL | |
| 350: | TFPNSTEEVK | AYCDMDMGGG | GWTVIQHRED | GSVDFQRTWK | EYKEGFGSPL | |
| 400: | GEYWLGNEFV | SQLTSGHRYV | LKIQLKDWEG | SEAHSLYEHF | YLSGEESNYR | |
| 450: | IHLTGLTGTA | GKISSISQPG | SDFSTKDSDN | DKCICKCSQM | LTGGWWFDAC | |
| 496: | GPSNLNGQYY | PQKQNTNKFN | GIKWYYWKGS | GYSLKATTMM | IRPADF |
| 3D Structure: | N/A |
| Pfam: | PF00147 |
| UniGene: | Rn.138360 |
| String: | O35462 |
| KEGG: | rno:89805 |
| SMR: | O35462 |
| Uniprot: | O35462 |