| Gene name: | ANGPT2; |
| Protein name: | Angiopoietin-2(ANG-2); |
| Alternative: | |
| Organism: | Pig (Sus scrofa). |
| Sub Unit: | N/A |
| Function: | Can induce tyrosine phosphorylation of TIE2. Binds to Binds to TIE2 receptor and counteracts blood vessel maturation/stability mediated by angiopoietin-1. Its function may be context-dependent. In the absence of angiogenic inducers, such as VEGF, ANG2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal. |
| Subcellular Location: | Secreted |
| Sequence length: | 496 |
| Sequence: | |
| 50: | MWQLVFFALS | CDLVLAAAYN | NFRKSMDSTG | KRQYQVQHGP | CSYTFLLPET | |
| 100: | DNCRSPSSSY | VSNAVQRDAP | LDYDDSVRRL | QVLENIMENN | TQWLMKLESY | |
| 150: | IQDNMKKEMV | EIQQNAVQNQ | TAVMIEIGTN | LLNQTAEQTR | KLTDVEAQVL | |
| 200: | NQTTRLELQL | LEHSLSTNKL | EKQILDQTSE | INKLQDKNSF | LEKKVLDMED | |
| 250: | KHIVQLQSIK | EEKDQLQVLV | SKQNSIIEEL | EKQLVTATVN | NSVLQKQQHD | |
| 300: | LMETVHNLLT | MISTSNSAKH | SLVAKEEQII | FRDCAEAFKS | GLTTSGTYTL | |
| 350: | TFPNSTEETK | AYCDMETGGG | GWTVIQRRED | GSVDFQRTWK | EYKMGFGSPS | |
| 400: | GEHWLGNEFV | SQVTNQKRYV | LKIHLRDWEG | NEAYSLYEHF | YLSSEEFNYR | |
| 450: | IHLKGLTGTA | GKISSISQPG | NDFSTKDADN | DKCICKCSQM | LTGGWWFDAC | |
| 496: | GPSNLNGMYY | PQRQNTNKFN | GIKWYYWKGS | GYSLKATTMM | IRPADF |
| 3D Structure: | N/A |
| KEGG: | ssc:396730 |
| UniGene: | Ssc.240 |
| Pfam: | PF00147 |
| SMR: | Q9BDY7 |
| String: | Q9BDY7 |
| Uniprot: | Q9BDY7 |