Gene name: | Angpt2(Agpt2); |
Protein name: | Angiopoietin-2(ANG-2); |
Alternative: | |
Organism: | Mouse (Mus musculus). |
Sub Unit: | N/A |
Function: | Can induce tyrosine phosphorylation of TIE2. Binds to Binds to TIE2 receptor and counteracts blood vessel maturation/stability mediated by angiopoietin-1. Its function may be context-dependent. In the absence of angiogenic inducers, such as VEGF, ANG2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal. |
Subcellular Location: | Secreted |
Sequence length: | 496 |
Sequence: | |
50: | MWQIIFLTFG | WDLVLASAYS | NFRKSVDSTG | RRQYQVQNGP | CSYTFLLPET | |
100: | DSCRSSSSPY | MSNAVQRDAP | LDYDDSVQRL | QVLENILENN | TQWLMKLENY | |
150: | IQDNMKKEMV | EIQQNVVQNQ | TAVMIEIGTS | LLNQTAAQTR | KLTDVEAQVL | |
200: | NQTTRLELQL | LQHSISTNKL | EKQILDQTSE | INKLQNKNSF | LEQKVLDMEG | |
250: | KHSEQLQSMK | EQKDELQVLV | SKQSSVIDEL | EKKLVTATVN | NSLLQKQQHD | |
300: | LMETVNSLLT | MMSSPNSKSS | VAIRKEEQTT | FRDCAEIFKS | GLTTSGIYTL | |
350: | TFPNSTEEIK | AYCDMDVGGG | GWTVIQHRED | GSVDFQRTWK | EYKEGFGSPL | |
400: | GEYWLGNEFV | SQLTGQHRYV | LKIQLKDWEG | NEAHSLYDHF | YLAGEESNYR | |
450: | IHLTGLTGTA | GKISSISQPG | SDFSTKDSDN | DKCICKCSQM | LSGGWWFDAC | |
496: | GPSNLNGQYY | PQKQNTNKFN | GIKWYYWKGS | GYSLKATTMM | IRPADF |
3D Structure: | N/A |
Pfam: | PF00147 |
KEGG: | mmu:11601 |
UniGene: | Mm.439874 |
SMR: | O35608 |
String: | O35608 |
Uniprot: | O35608 |