| Gene name: | ANGPT2; |
| Protein name: | Angiopoietin-2(ANG-2); |
| Alternative: | |
| Organism: | Human (Homo sapiens). |
| Sub Unit: | N/A |
| Function: | Can induce tyrosine phosphorylation of TIE2. Binds to TIE2 receptor and counteracts blood vessel maturation/stability mediated by angiopoietin-1. Its function may be context-dependent. In the absence of angiogenic inducers, such as VEGF, ANG2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal. |
| Subcellular Location: | Secreted |
| Sequence length: | 496 |
| Sequence: | |
| 50: | MWQIVFFTLS | CDLVLAAAYN | NFRKSMDSIG | KKQYQVQHGS | CSYTFLLPEM | |
| 100: | DNCRSSSSPY | VSNAVQRDAP | LEYDDSVQRL | QVLENIMENN | TQWLMKLENY | |
| 150: | IQDNMKKEMV | EIQQNAVQNQ | TAVMIEIGTN | LLNQTAEQTR | KLTDVEAQVL | |
| 200: | NQTTRLELQL | LEHSLSTNKL | EKQILDQTSE | INKLQDKNSF | LEKKVLAMED | |
| 250: | KHIIQLQSIK | EEKDQLQVLV | SKQNSIIEEL | EKKIVTATVN | NSVLQKQQHD | |
| 300: | LMETVNNLLT | MMSTSNSAKD | PTVAKEEQIS | FRDCAEVFKS | GHTTNGIYTL | |
| 350: | TFPNSTEEIK | AYCDMEAGGG | GWTIIQRRED | GSVDFQRTWK | EYKVGFGNPS | |
| 400: | GEYWLGNEFV | SQLTNQQRYV | LKIHLKDWEG | NEAYSLYEHF | YLSSEELNYR | |
| 450: | IHLKGLTGTA | GKISSISQPG | NDFSTKDGDN | DKCICKCSQM | LTGGWWFDAC | |
| 496: | GPSNLNGMYY | PQRQNTNKFN | GIKWYYWKGS | GYSLKATTMM | IRPADF |
| 3D Structure: | N/A |
| KEGG: | hsa:285 |
| Pfam: | PF00147 |
| String: | O15123 |
| SMR: | O15123 |
| MIM: | 601922 |
| UniGene: | Hs.583870 |
| STRING: | 9606.ENSP00000314897 |
| Uniprot: | O15123 |