| Gene name: | ANGPT2; |
| Protein name: | Angiopoietin-2(ANG-2); |
| Alternative: | |
| Organism: | Dog (Canis familiarisCanis lupus familiaris). |
| Sub Unit: | N/A |
| Function: | Can induce tyrosine phosphorylation of TIE2. Binds to Binds to TIE2 receptor and counteracts blood vessel maturation/stability mediated by angiopoietin-1. Its function may be context-dependent. In the absence of angiogenic inducers, such as VEGF, ANG2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal. |
| Subcellular Location: | Secreted |
| Sequence length: | 495 |
| Sequence: | |
| 50: | MWQIVFFTLS | CDLVRAAAYN | NFRRSMDSIG | RRQYQVQHGS | CSYTFLLPET | |
| 100: | DNCRSPGSYV | PNAVQRDAPL | DYDDSVQRLQ | VLENIMENNT | QWLIKLENYI | |
| 150: | QDNMKKEMVE | MQQNAVQNQT | AVMIEIGTNL | LNQTAEQTRK | LTDVEAQVLN | |
| 200: | QTTRLELQLL | EHSLSTNKLE | KQILDQTSEI | NKLQDKNSFL | EKKVLDMEDK | |
| 250: | HIVQLRSIKE | EKDQLQVLVS | KQNSIIEELE | KQLVTATVNN | SVLQKQQHDL | |
| 300: | METVHSLLTM | ISPSKSPKDT | FVAKEEQIIY | RDCAEVFKSG | LTTNGIYTLT | |
| 350: | FPNSTEEIKA | YCDMETSGGG | WTVIQRREDG | SVDFQRTWKE | YKVGFGNPSG | |
| 400: | EHWLGNEFVF | QVTNQQPYVL | KIHLKDWEGN | EAYSLYEHFY | LSGEELNYRI | |
| 450: | HLKGLTGTAG | KISSISQPGN | DFSTKDADND | KCICKCSQML | TGGWWFDACG | |
| 495: | PSNLNGMYYP | QRQNTNKFNG | IKWYYWKGSG | YSLKGTTMMI | RPADF |
| 3D Structure: | N/A |
| STRING: | 9615.ENSCAFP00000012671 |
| KEGG: | cfa:607616 |
| SMR: | A0A8J8 |
| Pfam: | PF00147 |
| UniGene: | Cfa.13296 |
| Uniprot: | A0A8J8 |