| Gene name: | ANGPT2(ANG2); |
| Protein name: | Angiopoietin-2(ANG-2); |
| Alternative: | |
| Organism: | Bovine (Bos taurus). |
| Sub Unit: | N/A |
| Function: | Can induce tyrosine phosphorylation of TIE2. Binds to Binds to TIE2 receptor and counteracts blood vessel maturation/stability mediated by angiopoietin-1. Its function may be context-dependent. In the absence of angiogenic inducers, such as VEGF, ANG2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal. |
| Subcellular Location: | Secreted |
| Sequence length: | 496 |
| Sequence: | |
| 50: | MWQLVFLTLS | CDLAVATAHS | GSRKGMDIAA | GKKQYQVQHG | ACSYTFLLPE | |
| 100: | TDHCRSPSSA | YVPNAVQRDA | PLDYDDSVQR | LQVLENIMEN | NTQWLMKLEN | |
| 150: | YIQDNMKKEM | VEIQQNAVQN | QTAVMIEIGT | NLLNQTAEQT | RKLTDVEAQV | |
| 200: | LNQTTRLELQ | LLEHSLSTNK | LEKQILDQTS | EISKLQDKNS | FLEKKVLDME | |
| 250: | DKHIVQLRSI | KEEKDQLQVL | VSKQNSIIEE | LEKQLVTATV | NNSVLQKQQH | |
| 300: | DLMETVNNLL | TLMSTSNPSY | SLLAKDEQII | FRDCGEAFKS | GLTTSGVYTL | |
| 350: | TFPNSTEEIK | AYCDMETGGG | GWTVIQRRED | GSVDFQRTWK | EYKVGFGNPS | |
| 400: | GEHWLGNEFV | SQVTGQKRYV | LKIHLRDWEG | NEAYSLYDHF | YLSNEELNYR | |
| 450: | IHLKGLTGTA | GKISSISQPG | NDFSTKDADN | DKCICKCSQM | LTGGWWFDAC | |
| 496: | GPSNLNGMYY | PQRQNTNKFN | GIKWYYWKGS | GYSLKATTMM | IRPADF |
| 3D Structure: | N/A |
| Pfam: | PF00147 |
| KEGG: | bta:282141 |
| String: | O77802 |
| SMR: | O77802 |
| UniGene: | Bt.137 |
| STRING: | 9913.ENSBTAP00000014656 |
| Uniprot: | O77802 |